 |








 |
jwz | |
 |
 |
 |
 |
|
 |
 |
Super Strength Substance One Step Closer to Human Trials You may remember Liam Hoekstra, the baby apparently born without the myostatin gene, and similarly enabled animals that have absurd strength. Using gene therapy, NCH scientists were able to get follistatin (a myostatin blocker) to promote phenomenal muscle growth in the quadriceps of macaque monkeys. NCH is now working with the FDA to perform the preliminary steps necessary for a human clinical trial. We could see a superman gene therapy available in the next decade. Macaques were observed for 15 months after receiving a gene therapy that promoted follistatin (and blocked myostatin) in their quadriceps. There was no observed damage to internal organs, the treatment only seemed to affect skeletal muscle, the reproductive cycles and cells functioned normally, and there was no reported damaged to tendons or ligaments. The macaques exhibited enhanced muscle growth for 12 weeks after treatment, beyond which muscle mass stabilized. The average circumference of the animals quadriceps increased by 15%. Using electric stimulation (you can't order a monkey to lift weights) scientists were able to observe profound increases in leg strength. One specimen demonstrated a 78% increase over control results. Along with Muscular Dystrophy treatments, and therapies for muscle loss in old age, the defeat of myostatin could lead to an effective way for all of us to get fit fast. No workouts necessary, eat almost all you want, and have a body like Adonis. However, if there's one thing I'm sure we DON'T need, it's super-powered Macaques.
Tags: mad science, mutants, the future Current Music: Placebo -- Space Monkey
|
 |
 |
 |
 |
|
 |
 |


 |
tongodeon | |
 |
 |
 |
 |
|
 |
 |
This picture, taken today, shows the first four floors of One World Trade, formerly known as The Freedom Tower. It's good to see it finally getting built.  A lot of people have complained about the slow progress of the bureaucracy. It's been eight years since the attacks and we're just getting started. On the other hand I was thinking that this isn't Amazon.com where you can just order a new World Trade Center and UPS delivers it 24 hours later. First Ground Zero was a disaster/crime scene, then it was a massive engineering project combined with a massive fortification project since the building will probably be attacked again. If 8 years is too long what's a reasonable amount of time to spend planning before work starts? Let's compare to the original. The original World Trade Center was first proposed in 1946 by the New York Legislature and put into motion by Mayor Dewey, but the plans were put on hold in 1949. David Rockefeller re-proposed the idea in a meeting on Oct. 31, 1955. Initial plans were made public in 1961, architects were selected on September 20, 1962, Minoru Yamasaki's design was unveiled publicly on January 18, 1964, and the Port Authority began buying up the property in March 1965. Demolition work began on March 21, 1966, actual groundbreaking began on August 5, 1966, but construction of the North Tower didn't actually begin until August 1968. The building wasn't "topped off" until December 23, 1970. I could say that the first World Trade Center took more than 24 years to build. Then again that's counting a lot of political wrangling and gridlock. Then again people bitching today are bitching about political wrangling and gridlock, so maybe we should consider this thing apples to apples. On the other hand the land was already owned by the Port Authority when the towers were hit, and there was nearly unanimous agreement to build the towers back, so it's not like they were starting from square one. If we mark the "start" of both projects as the time when the initial plans were unveiled (January 1964 and January 2004 respectively) the rebuilt WTC broke ground 98 days *earlier* than the original. I'd like to see it get built sooner rather than later, but as far as I can tell we're slightly under par right now. If things continue as they did the first time, the new WTC ought to be topped off in December 2010. (I made a timeline to compare details.)
|
 |
 |
 |
 |
|
 |
 |



|
 |
|
 |